Ocular abnormalities involve the anterior chamber, and in most patients consist of Peters anomaly, which is characterized by corneal clouding and iridolenticulocorneal adhesions. What are the different ways a genetic condition can be inherited? Wieacker P, Rehder H. Hydrocephalus, agenesis of the corpus callosum, and cleft Do you have updated information on this disease? What are the main symptoms of Peters plus syndrome? lip/palate represent frequent associations in fetuses with Peters' plus syndrome white). Peters anomaly is a rare congenital form of anterior segment dysgenesis in which abnormal cleavage of the anterior chamber occurs. The HPO Peters-plus syndrome or Krause–Kivlin syndrome is a hereditary syndrome defined by Peters' anomaly, dwarfism and intellectual disability. Peters Plus Syndrome. Fetal PPS phenotypes, expanded by Dandy Walker cyst and Ann Genet. Peters anomaly involves thinning and clouding of the cornea and attachment of the iris to the cornea, which causes blurred vision. An eye problem called Peters anomaly is the most common anterior chamber abnormality seen in Peters plus syndrome. Developmental milestones, such as walking and speech, are delayed in most children with Peters plus syndrome. 10.1002/ajmg.a.32498. Peters plus syndrome is an inherited condition that is characterized by eye abnormalities, short stature, an opening in the lip (cleft lip) with or without an opening in the roof of the mouth (cleft palate), distinctive facial features, and intellectual disability. Peters anomaly is characterized by eye problems that occur in an area at the front part of the eye known as the anterior segment. Have a question? diagnosis by anterior segment exam in infants found to have corneal opacification present at birth. Fewer than 80 people with this condition have been reported worldwide. Peters Plus syndrome occurs when Peters anomaly is associated with short-limb dwarfism and learning disability. MedlinePlus links to health information from the National Institutes of Health and other federal government agencies. The eye problems in Peters plus syndrome occur in an area at the front part of the eye known as the anterior segment. We want to hear from you. This causes abnormalities in the structures in the front of the eye. An eye problem called Peters anomaly is the most common anterior chamber abnormality seen in Peters plus syndrome. Other less common symptoms may include heart and kidney abnormalities. Peters-plus syndrome consists of Peters anomaly plus various degrees of developmental delays and intellectual deficits, short digits and short stature, and cleft lip and palate. Peters anomaly involves thinning and clouding of the cornea and attachment of the iris to the cornea, which causes blurred vision. Peters anomaly with short limb dwarfism; Krause-Kivlin syndrome, Congenital disorder of glycosylation with developmental anomaly, placeholder for the horizontal scroll slider, Office of Rare Disease Research Facebook Page, Office of Rare Disease Research on Twitter, U.S. Department of Health & Human Services, Caring for Your Patient with a Rare Disease, Preguntas Más Frecuentes Sobre Enfermedades Raras, Como Encontrar un Especialista en su Enfermedad, Consejos Para una Condición no Diagnosticada, Consejos Para Obtener Ayuda Financiera Para Una Enfermedad, Preguntas Más Frecuentes Sobre los Trastornos Cromosómicos, Human Phenotype Ontology Mean age at first presentation was 5 years; mean follow-up period censored in terms of eyeball preservation was 2 years (0 months-8 years). What does it mean if a disorder seems to run in my family? In normal conditions, it is a transparent tissue due to the absence of blood vessels and the distribution of the fibres comprising it. In this condition, the central part of the cornea is opaque (i.e. Peters anomaly-cataract syndrome Peters plus syndrome.